Ultrastructural and biochemical changes in epididymis and vas deferens of gossypol treated rats.
Indian J Exp Biol
;
1989 Jun; 27(6): 510-8
Article
in English
| IMSEAR
| ID: sea-59641
ABSTRACT
Adult male Wister rats when administered with 15 mg/kg body weight/day of gossypol acetic acid proved to be sterile by 10 weeks of treatment. The weight of the whole epididymis did not deviate from the controls but when the caput, corpus and cauda epididymidis were considered separately, the cauda epididymidis weight was significantly reduced. The major changes were observed in the motor apparatus of the sperm. The most common defects in the sperm were the vacuolization and complete degeneration of the midpiece mitochondria and plasma membrane. The total LDH activity of caput and cauda epididymidis were within the range of control values. Sialic acid levels of the epididymis were not affected after the treatment. These results suggest a more proximal site of action of the drug than at the epididymal level.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Organ Size
/
Rats
/
Rats, Inbred Strains
/
Sialic Acids
/
Vas Deferens
/
Male
/
Gossypol
/
Microscopy, Electron
/
Organelles
/
Cell Membrane
Language:
English
Journal:
Indian J Exp Biol
Year:
1989
Type:
Article
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