Preparation and in vitro evaluation of liposomal/niosomal delivery systems for antifungal drug clotrimazole.
Indian J Exp Biol
;
2005 Feb; 43(2): 150-7
Article
in English
| IMSEAR
| ID: sea-59646
ABSTRACT
Clotrimazole, an imidazole derivative antifungal agent is widely used for the treatment of mycotic infections of the genitourinary tract. In order to develop alternative formulation for the vaginal administration of clotrimazole to provide sustained and controlled release of appropriate drug for local vaginal therapy, liposomes/niosomes were evaluated as delivery vehicles. To optimize the preparation of liposomes/niosomes with regards to size and entrapment efficiency, multilamellar liposomes/niosomes containing drug were prepared by lipid hydration method. The ability of the systems to deliver clotrimazole into and through the mucosa was evaluated in vitro using rabbit vaginal mucosa with vertical Franz diffusion cells. The in vitro permeation data showed that the liposomes/niosomes system increased the clotrimazole total penetration through the vaginal mucosa by 1.6, 1.5-fold, the accumulation of clotrimazole into the mucosa was increased by 3.1, 2.3-fold, respectively, as compared with control during 24 hr. These results suggest that the studied liposomes/niosomes systems may be appropriate vesicles for the vaginal mucosa delivery of clotrimazole for local vaginal therapy.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Particle Size
/
Permeability
/
Rabbits
/
Solubility
/
Vagina
/
Female
/
Administration, Topical
/
Drug Delivery Systems
/
Clotrimazole
/
Drug Stability
Language:
English
Journal:
Indian J Exp Biol
Year:
2005
Type:
Article
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