In vivo effects of acetaminophen on rat RBC and role of vitamin E.
Indian J Exp Biol
;
1995 Apr; 33(4): 269-71
Article
in English
| IMSEAR
| ID: sea-59756
ABSTRACT
Non-therapeutic toxic dose (250 mg/kg) of acetaminophen (paracetamol), in vivo to albino rats significantly decreased red cell reduced glutathione (GSH) content and activity of (Na+, K+)-ATPase enzyme, whereas osmotic fragility (O.F.) was increased. However, no change was observed in the activity of glutathione reductase (GR) after acetaminophen treatment, while acetaminophen plus vitamin E treated rats showed significant increase in GR activity. Supplementation of vitamin E to the drug treated rats effectively brought the GSH content, (Na+, K+)-ATPase activity and O.F. back to almost normal. The results suggest that acetaminophen toxic dose treatment induces metabolic and membranal alterations making red cells prone to hemolysis, while vitamin E which is an antioxidant shows its ameliorating role to these changes.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Vitamin E
/
Male
/
Analgesics, Non-Narcotic
/
Erythrocytes
/
Animals
/
Acetaminophen
Language:
English
Journal:
Indian J Exp Biol
Year:
1995
Type:
Article
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