Changes in levels of lipid peroxides and activity of superoxide dismutase and catalase in diabetes associated with myocardial infarction.
Indian J Exp Biol
;
1992 Feb; 30(2): 122-7
Article
in English
| IMSEAR
| ID: sea-59843
ABSTRACT
Studies were carried out on the metabolism of lipid peroxides and antioxidative enzymes during diabetes and diabetes superimposed with myocardial infarction. Diabetes was induced using alloxan and myocardial infarction was induced by isoproterenol. In the case of diabetic animals there was a decrease in the levels of lipid peroxides in the heart while in the case of diabetes associated with myocardial infarction it was slightly elevated. The activity of superoxide dismutase and catalase showed a decrease in both the groups. Glutathione showed a fall in the case of diabetes and diabetes associated with myocardial infarction while taurine in heart and ceruloplasmin in the serum was elevated. Histopathological changes in the heart tissue showed some focal changes in the case of both diabetes and diabetes associated with myocardial infarction, but the degree of necrosis was much less than in the case of myocardial infarction.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Rats, Inbred Strains
/
Superoxide Dismutase
/
Male
/
Catalase
/
Diabetes Mellitus, Experimental
/
Glutathione
/
Lipid Peroxides
/
Animals
/
Myocardial Infarction
Language:
English
Journal:
Indian J Exp Biol
Year:
1992
Type:
Article
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