Involvement of p38 Mapkinase in attenuation of antinociceptive effect of morphine in diabetic mice.

Gilhotra, Neeraj; Sharma, Ajay; Singh, Manjeet

Gilhotra, Neeraj; Sharma, Ajay; Singh, Manjeet.

Indian J Exp Biol ; 2007 Jul; 45(7): 654-6

Article in English | IMSEAR | ID: sea-59884

ABSTRACT

ABSTRACT

Experimental diabetes induced by streptozotocin (200 mg/kg, ip) markedly decreased the antinociceptive effect of morphine and significantly increased the urinary nitrite concentration. Administration of FR-167653 (a selective p38MAPKinase inhibitor) in a dose of 4 mg/kg improved the antinociceptive effect of morphine and attenuated the increase in urinary nitrite concentration in diabetic mice. It may be concluded that diabetes-induced decrease in antinociceptive effect of morphine may be due to induction of p38 MAPKinase activity.

Subject(s)

Analgesics/pharmacology; Analgesics, Opioid/pharmacology; Animals; Blood Glucose/metabolism; Cyclooxygenase Inhibitors/chemistry; Drug Design; Female; Male; Mice; Models, Statistical; Morphine/pharmacology; Nitrites/chemistry; Pyrazoles/pharmacology; Pyridines/pharmacology; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Pyrazoles / Pyridines / Blood Glucose / Female / Male / Drug Design / Models, Statistical / Cyclooxygenase Inhibitors / P38 Mitogen-Activated Protein Kinases / Analgesics Type of study: Risk factors Language: English Journal: Indian J Exp Biol Year: 2007 Type: Article

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