Involvement of p38 Mapkinase in attenuation of antinociceptive effect of morphine in diabetic mice.
Indian J Exp Biol
;
2007 Jul; 45(7): 654-6
Article
in English
| IMSEAR
| ID: sea-59884
ABSTRACT
Experimental diabetes induced by streptozotocin (200 mg/kg, ip) markedly decreased the antinociceptive effect of morphine and significantly increased the urinary nitrite concentration. Administration of FR-167653 (a selective p38MAPKinase inhibitor) in a dose of 4 mg/kg improved the antinociceptive effect of morphine and attenuated the increase in urinary nitrite concentration in diabetic mice. It may be concluded that diabetes-induced decrease in antinociceptive effect of morphine may be due to induction of p38 MAPKinase activity.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pyrazoles
/
Pyridines
/
Blood Glucose
/
Female
/
Male
/
Drug Design
/
Models, Statistical
/
Cyclooxygenase Inhibitors
/
P38 Mitogen-Activated Protein Kinases
/
Analgesics
Type of study:
Risk factors
Language:
English
Journal:
Indian J Exp Biol
Year:
2007
Type:
Article
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