Effect of myosin B on guinea pig muscles--light microscopic and immunological aspects.
Indian J Exp Biol
;
1994 Jun; 32(6): 405-8
Article
in English
| IMSEAR
| ID: sea-60011
ABSTRACT
Experimental myositis was induced in guinea pigs by multiple inoculations with Myosin B fraction of the rabbit skeletal muscle. Quantitative histopathological features were studied and they include necrosis, central nucleation, inflammatory cellular reaction. Besides myositis, features of myocarditis were evident in 40% animals. Circulating immune complexes (CICs) in the sera of experimental animals were isolated by a polyethylene glycol (PEG) precipitation method. Presence of antimyosin B antibody in the immune complexes was characterised by an enzyme-linked immunosorbent assay. The role of circulating immune complexes in pathogenesis of experimental myositis and human polymyositis have been emphasised.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Male
/
Myosins
/
Immunization
/
Muscle, Skeletal
/
Guinea Pigs
/
Animals
/
Microscopy
/
Myositis
/
Antigen-Antibody Complex
Language:
English
Journal:
Indian J Exp Biol
Year:
1994
Type:
Article
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