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Cancer preventive potential of Momordica charantia L. against benzo(a)pyrene induced fore-stomach tumourigenesis in murine model system.
Indian J Exp Biol ; 2004 Mar; 42(3): 319-22
Article in English | IMSEAR | ID: sea-60046
ABSTRACT
Bitter melon ( Momordica charantia Linnaeus) fruit extract was tested against 3,4 benzo(a)pyrene [B(a)P] induced forestomach papillomagenesis in Swiss albino mice. Extract of M. charantia in two concentrations, 2.5 and 5% of standard mice feed was used for the short-term and long-term studies. A significant decrease in tumour burden was observed in short and long-term treatment. Also, total tumour incidence reduced to 83.33% with 2.5% dose and 90.90% with 5% dose in short term treatment, while in long-term treatment tumor incidence decreased to 76.92% with 2.5% dose and 69.23% with 5% dose of M. charantia. The possible mechanism involved in the cancer chemoprevention has also been discussed.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Stomach Neoplasms / Benzo(a)pyrene / Body Weight / Male / Plant Extracts / Carcinogens / Anticarcinogenic Agents / Momordica charantia / Animals / Mice Language: English Journal: Indian J Exp Biol Year: 2004 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Stomach Neoplasms / Benzo(a)pyrene / Body Weight / Male / Plant Extracts / Carcinogens / Anticarcinogenic Agents / Momordica charantia / Animals / Mice Language: English Journal: Indian J Exp Biol Year: 2004 Type: Article