Antiulcer activity of N-phthaloyl GABA--a new GABA mimetic agent.
Indian J Exp Biol
;
1990 Feb; 28(2): 190-2
Article
in English
| IMSEAR
| ID: sea-60068
ABSTRACT
N-phthaloyl GABA (P. GABA) inhibited gastric ulceration induced by 3 hr restraint stress at 4 degrees C (CRS) in albino rats. Antiulcer activity of P. GABA was compared with sodium valproate and cimetidine. P. GABA, sodium valproate and cimetidine showed a dose dependent reduction of gastric ulceration. Pretreatment with GABA antagonists-bicuculline methiodide (0.5 mg/kg, im) or 3 mercaptopropionic acid (2 mg/kg, im) reversed the antiulcerogenic activity of both the drugs (P. GABA and sodium valproate). GABA antagonists as such did not induce gastric ulceration in normal rats.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Stomach Ulcer
/
Bicuculline
/
Male
/
Valproic Acid
/
Cimetidine
/
Dose-Response Relationship, Drug
/
Gamma-Aminobutyric Acid
/
Animals
/
3-Mercaptopropionic Acid
Language:
English
Journal:
Indian J Exp Biol
Year:
1990
Type:
Article
Similar
MEDLINE
...
LILACS
LIS