CNS depressive role of aqueous extract of Spinacia oleracea L. leaves in adult male albino rats.

Das, Sutapa; Guha, Debjani

Das, Sutapa; Guha, Debjani.

Indian J Exp Biol ; 2008 Mar; 46(3): 185-90

Article in English | IMSEAR | ID: sea-60069

ABSTRACT

ABSTRACT

Treatment with Spinacia oleracea extract (SO; 400 mg/kg body weight) decreased the locomotor activity, grip strength, increased pentobarbitone induced sleeping time and also markedly altered pentylenetetrazole induced seizure status in Holtzman strain adult male albino rats. SO increased serotonin level and decreased both norepinephrine and dopamine levels in cerebral cortex, cerebellum, caudate nucleus, midbrain and pons and medulla. Result suggests that SO exerts its CNS depressive effect in PTZ induced seizure by modulating the monoamines in different brain areas.

Subject(s)

Animals; Anticonvulsants/pharmacology; Antidepressive Agents/pharmacology; Biogenic Monoamines/metabolism; Central Nervous System/metabolism; Dopamine/metabolism; Male; Motor Activity/drug effects; Norepinephrine/metabolism; Pentylenetetrazole/toxicity; Phytotherapy/methods; Plant Extracts/chemistry; Plant Leaves/chemistry; Rats; Rats, Sprague-Dawley; Seizures/chemically induced; Serotonin/metabolism; Spinacia oleracea/chemistry

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Pentylenetetrazole / Rats / Seizures / Male / Plant Extracts / Biogenic Monoamines / Dopamine / Serotonin / Norepinephrine / Central Nervous System Language: English Journal: Indian J Exp Biol Year: 2008 Type: Article

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