Effect of simvastatin on fracture healing--an experimental study.
Indian J Exp Biol
;
2007 May; 45(5): 444-9
Article
in English
| IMSEAR
| ID: sea-60106
ABSTRACT
Left femur was osteotomized and fixed with K wire in 21 rabbits. One group was fed simvastatin (120 mg/kg body wt/day) orally, whereas another group without medication served as control. Both groups were assessed radiologically, morphologically, histologically and biomechanically at 4, 8 and 12 weeks. An analysis of various parameters of study showed that simvastatin treated group had improved bone healing at 4 and 8 weeks of follow up, however, the difference was not significant statistically at 12 weeks. So it is concluded that Simvastatin favourably hastened the process of fracture healing in the rabbits at earlier phases.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rabbits
/
Stress, Mechanical
/
Time Factors
/
Bone Resorption
/
Bony Callus
/
Fracture Healing
/
Simvastatin
/
Fractures, Bone
/
Femur
/
Animals
Type of study:
Evaluation studies
Language:
English
Journal:
Indian J Exp Biol
Year:
2007
Type:
Article
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