Oxidative stress in rat liver and lung induced by furanoterpenoids isolated from Fusarium solani infected sweet potatoes.
Indian J Exp Biol
;
1996 Jan; 34(1): 57-60
Article
in English
| IMSEAR
| ID: sea-60107
ABSTRACT
A crude extract containing some toxic furanoterpenoids was isolated from F. solani infected sweet potatoes. Chronic administration of the crude extract to male albino rats at a dosage of 1 mg/kg body weight/day for 21 days brought about a sharp increase in the thiobarbituric acid reactive substances and a depression of glutathione levels in the lung and liver homogenates. The antioxidant defense system was affected as evident from a significant fall in the activities of the enzymes, superoxide dismutase, catalase, glutathione peroxidase, glucose-6-phosphate dehydrogenase and glutathione-S-transferase. Such an alteration could be the reason for the lung and liver damage caused by these toxic furanoterpenoids.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Terpenes
/
Vegetables
/
Male
/
Rats, Wistar
/
Oxidative Stress
/
Furans
/
Fusarium
/
Liver
/
Lung
Language:
English
Journal:
Indian J Exp Biol
Year:
1996
Type:
Article
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