Antinociceptive effect of amitriptyline in mice of acute pain models.
Indian J Exp Biol
;
2007 Jun; 45(6): 529-31
Article
in English
| IMSEAR
| ID: sea-60128
ABSTRACT
Tricyclic antidepressant drugs induce antinociceptive effect and suggest that their analgesic action could be related to the monoaminergic activity of the drugs. The analgesic activity of amitriptyline was observed in mouse models of acute pain. Mice were divided into different groups and were given amitriptyline in different doses alone and in combination with morphine. Reaction time in Hot-Plate and Tail-Flick tests was observed. Results showed that amitriptyline had antinociceptive effect in acute pain state in experimental models. Amitriptyline in combination with morphine had better analgesic effect than the morphine alone in Hot-Plate test.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pain
/
Acute Disease
/
Analgesics, Non-Narcotic
/
Disease Models, Animal
/
Dose-Response Relationship, Drug
/
Amitriptyline
/
Animals
/
Mice
Type of study:
Evaluation studies
Language:
English
Journal:
Indian J Exp Biol
Year:
2007
Type:
Article
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