Effect of Curcuma longa or parziquantel on Schistosoma mansoni infected mice liver--histological and histochemical study.
Indian J Exp Biol
;
2007 Oct; 45(10): 877-89
Article
in English
| IMSEAR
| ID: sea-60149
ABSTRACT
Effect of drug praziquantel (PZQ) and C. longa extract on S. mansoni infected mice is reported. The level of glycogen, alkaline and acid phosphatases (ALP and ACP respectively), and body weight, liver weight and liver weight/body weight ratio were studied in mice infected with S. mansoni. ALP level was increased after infection. C. longa treated mice showed marked reduction in ALP level more than after PZQ-treatment. C. longa enhanced the concentration of glycogen after being reduced by infection, while PZQ-treatment revealed more reduction. C. longa caused enhancement in body weight while PZQ treatment had no effect. The formation of granuloma around schistosome eggs in the liver produced inflammation. C. longa extract and PZQ were effective in reducing granuloma size in infected mice.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Organ Size
/
Praziquantel
/
Schistosoma mansoni
/
Body Weight
/
Schistosomiasis mansoni
/
Male
/
Plant Extracts
/
Curcuma
/
Alkaline Phosphatase
/
Liver Diseases
Language:
English
Journal:
Indian J Exp Biol
Year:
2007
Type:
Article
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