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Effect of antidiabetic compounds on glyoxalase I activity in experimental diabetic rat liver.
Indian J Exp Biol ; 1999 Feb; 37(2): 193-5
Article in English | IMSEAR | ID: sea-60174
ABSTRACT
The activity of glyoxalase I from the soluble fraction of diabetic rat liver was found to decrease as compared to the control. Sodium orthovanadate in drinking water and Trigonella foenum graecum seed powder when administered to these diabetic animals were found to reverse the activity of glyoxalase I to control values. A combination of the above two antidiabetic compounds showed a better reversal. Vanadate and Trigonella seed powder treatment separately to diabetic rats also normalized hyperglycemia together with glyoxalase I activity. A combination of vanadate and Trigonella seed powder also restored the other general parameters of the diabetic animals.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Plants, Medicinal / Rats / Female / Vanadates / Plant Extracts / Rats, Wistar / Trigonella / Diabetes Mellitus, Experimental / Hypoglycemic Agents / Lactoylglutathione Lyase Language: English Journal: Indian J Exp Biol Year: 1999 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Plants, Medicinal / Rats / Female / Vanadates / Plant Extracts / Rats, Wistar / Trigonella / Diabetes Mellitus, Experimental / Hypoglycemic Agents / Lactoylglutathione Lyase Language: English Journal: Indian J Exp Biol Year: 1999 Type: Article