Oral toxicity of Madhuca butyracea Macb. saponins to albino rats.
Indian J Exp Biol
;
1990 Jul; 28(7): 642-7
Article
in English
| IMSEAR
| ID: sea-60241
ABSTRACT
Saponins, isolated from M. butyracea, were assessed for their acute and subacute oral toxicity in albino rats. Acute doses of saponins caused mortalities and LD50 and LD90 values were 330 and 430 mg/kg body wt respectively. Severe diarrhoea, restlessness and histopathological changes were observed in liver and kidney. Diets containing saponins at 0,250,500 and 1000 ppm for 14 weeks did not affect food intake, growth or organ weights, but induced mild histological changes in liver and kidney and altered the serum levels of alkaline phosphatase, blood urea nitrogen, cholesterol and proteins, particularly in female rats.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Rats, Inbred Strains
/
Saponins
/
Seeds
/
Trees
/
Female
/
Male
/
Plant Extracts
/
Random Allocation
/
Sex Factors
Language:
English
Journal:
Indian J Exp Biol
Year:
1990
Type:
Article
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