Prevention of chromate induced oxidative stress by alpha-lipoic acid.
Indian J Exp Biol
;
2005 Jun; 43(6): 531-5
Article
in English
| IMSEAR
| ID: sea-60259
ABSTRACT
The parenteral administration of alpha-lipoic acid (LA) protected against chromate induced oxidative stress in mouse liver. A shift in Cr induced pro-oxidant state to antioxidant-state by LA was noteworthy. The degree of protection was significant and similar in different LA administration regimens (prior-, co- and post- parenteral Cr exposure) explored. An improved status of the tissue antioxidants by LA appeared to be the mechanism of mitigation. The results are of chemopreventive value and suggest a possible alternative to ascorbic acid for abrogation of Cr toxicity.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Oxygen
/
Potassium Dichromate
/
Superoxide Dismutase
/
Time Factors
/
Male
/
Carbon
/
Lipid Peroxidation
/
Catalase
/
Chromates
/
Chromium
Language:
English
Journal:
Indian J Exp Biol
Year:
2005
Type:
Article
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