Damage induction by direct electric current in tumoural target cells.
Indian J Exp Biol
;
2000 Jun; 38(6): 554-8
Article
in English
| IMSEAR
| ID: sea-60353
ABSTRACT
Damage induction to tumour target cells (P815) by direct electric current (DC) was investigated. A 6 min treatment of P815 cells with DC generated decreased levels of cell viability and proliferation. The ultrastructural analysis of DC-treated cells revealed the presence of blebs, loss of cell surface filopodia, and ruptures in cell membrane. Mitochondrial alterations, swelling of cells, cytoplasmic matrix rarefaction, and cellular debri formation were also observed. The study shows that tumoural target cells can be damaged by direct electric current and this approach may provide means to understand the mechanism of tumour regression induced by electrochemical therapy.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Tumor Cells, Cultured
/
Microscopy, Electron
/
Cell Division
/
Electric Stimulation Therapy
/
Cell Death
/
Mast-Cell Sarcoma
/
Electricity
/
Animals
/
Mice
Type of study:
Evaluation studies
Language:
English
Journal:
Indian J Exp Biol
Year:
2000
Type:
Article
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