Differential amplification and expression of c-myb oncogene in Zajdela ascitic hepatoma.
Indian J Exp Biol
;
1990 May; 28(5): 401-4
Article
in English
| IMSEAR
| ID: sea-60362
ABSTRACT
Organisation and expression of c-myb protooncogene have been studied in a heterogeneous tumour the Zajdela ascitic hepatoma (ZAH). The myb gene is selectively amplified in the more tumorigenic subpopulation of the tumour while the non-lethal subpopulation does not show any change. Analysis of transcripts of the myb gene in tumorigenic versus nontumorigenic cells shows that the level of amplification of the gene does not correspond to the level of its transcription. Results have been discussed in the light of existing evidence regarding the role of c-myb gene expression during cell cycle.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Proto-Oncogenes
/
DNA, Neoplasm
/
Gene Expression
/
Gene Amplification
/
Liver
/
Liver Neoplasms, Experimental
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
1990
Type:
Article
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