Identification and characterization of receptor for dengue virus-induced macrophage cytotoxin.
Indian J Exp Biol
;
1996 Jul; 34(7): 652-7
Article
in English
| IMSEAR
| ID: sea-60364
ABSTRACT
The present study was undertaken to identify the receptor for dengue virus type 2 (DV) induced macrophage cytotoxin (CF2) on mouse peritoneal macrophages (MPhi). The binding of 125I-labelled CF2 to MPhi was saturable (15 nM), reversible, temperature, pH- and time-dependent. The saturation concentration was similar to that causing cell death. Scatchard analysis showed the presence of intermediate type of affinity receptor and the number of receptor sites was 1.1 x 10(6) per cell with dissociation constant of 14.28 nM.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Receptors, Virus
/
Macrophages, Peritoneal
/
Cytotoxins
/
Dengue Virus
/
Animals
/
Mice
/
Mice, Inbred Strains
Type of study:
Prognostic study
Language:
English
Journal:
Indian J Exp Biol
Year:
1996
Type:
Article
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