Effect of fatty acid binding proteins on developing human placental malate dehydrogenase activity.
Indian J Exp Biol
;
1994 Nov; 32(11): 800-3
Article
in English
| IMSEAR
| ID: sea-60374
ABSTRACT
Role of fatty acid binding proteins (FABPs) in modulating inhibition of human placental malate dehydrogenase by palmitoyl-CoA and oleate has been studied. Activity of human placental cytosolic malate dehydrogenase is detected throughout the gestation, showing a peak at midgestation (20-25 weeks). Inhibition (50%) of the enzyme activity is obtained by 20 microM palmitoyl-CoA or 35 microM oleate. FABPs enhance the activity of malate dehydrogenase in absence of palmitoyl-CoA or oleate and also protect against palmitoyl-CoA or oleate inhibition. Such a modulatory effect of FABP may be due to the binding of long chain fatty acyl-CoA or fatty acid rather than a direct effect of FABPs on the enzyme.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Placenta
/
Female
/
Humans
/
Pregnancy
/
Carrier Proteins
/
Gestational Age
/
Tumor Suppressor Proteins
/
Fatty Acid-Binding Proteins
/
Fatty Acids
/
Malate Dehydrogenase
Language:
English
Journal:
Indian J Exp Biol
Year:
1994
Type:
Article
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