FSH, the neglected sibling: evidence for its role in regulation of spermatogenesis and Leydig cell function.
Indian J Exp Biol
;
2005 Nov; 43(11): 993-1000
Article
in English
| IMSEAR
| ID: sea-60465
ABSTRACT
The role of follicle stimulating harmone(FSH) in male reproductive function remains a matter of debate although recent evidences strongly suggest a role despite the controversies that arose following the results obtained with FSH-beta null mice and observations from human FSH receptor mutations. This review summarizes the recent developments of our understanding on the role of FSH in male reproduction. Specifically the results obtained with FSH-beta and FORKO null mice are be discussed in light of our observations employing active and passive neutralization of endogenous FSH in rodents and primates along with other studies. On the basis of results obtained employing a variety of models it can be conclude unequivocally that FSH regulates Leydig cell function and is essential for normal quantitative spermatogenesis.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Spermatogenesis
/
Testosterone
/
Receptors, FSH
/
Humans
/
Male
/
Mice, Knockout
/
Follicle Stimulating Hormone
/
Leydig Cells
/
Animals
/
Mice
Language:
English
Journal:
Indian J Exp Biol
Year:
2005
Type:
Article
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