Role of ATP-sensitive potassium channels in the piracetam induced blockade of opioid effects.
Indian J Exp Biol
;
2007 Dec; 45(12): 1050-4
Article
in English
| IMSEAR
| ID: sea-60492
ABSTRACT
The present study has been designed to investigate the effect of piracetam on morphine/ buprenorphine-induced antinociception in rats and effect of piracetam on morphine or minoxidil induced relaxation in KCl-precontracted isolated rat aortic ring preparation. Nociceptive threshold was measured by the tail flick test in rats. The cumulative dose responses of morphine or minoxidil were recorded in KCl-precontracted isolated rat aortic ring preparation. Piracetam attenuated buprenorphine-induced antinociception in rats. Piracetam significantly reduced the morphine and minoxidil induced relaxation in KCl precontracted isolated rat aortic ring preparation suggesting that piracetam interferes with opioid receptor and ATP-sensitive potassium channel (KATP) opener mediated responses in vitro. Thus, it may be suggested that piracetam attenuates opioid effects by an opioid receptor-KATP channel linked mechanism.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Piracetam
/
Rats
/
Male
/
Receptors, Opioid
/
Opioid Peptides
/
Neuroprotective Agents
/
KATP Channels
/
Analgesics, Opioid
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
2007
Type:
Article
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