Effects of paraquat on anti-oxidant system in rats.
Indian J Exp Biol
;
2007 May; 45(5): 432-8
Article
in English
| IMSEAR
| ID: sea-60515
ABSTRACT
The toxic effects of paraquat on the anti-oxidant defense system of male albino rats were evaluated, after administering either a single dose (1.5 and 7.5 mg/kg of body weight) or continuous daily doses (same as above, i.e., 1.5 mg/kg and 7.5 mg/kg of body weight) for 3 and 7 days. Glutathione levels in blood cells, liver, lung and kidney tissues decreased in a dose and time dependent manner. Glutathione reductase and glucose-6-phosphate dehydrogenase activity decreased, whereas the activity of glutathione-S-transferase, glutathione peroxidase, catalase and superoxide dismutase increased in paraquat exposure. Malondialdehyde formation also increased in a dose and time dependent manner. The alterations of anti-oxidant system particularly glutathione can be utilized as biomarkers during management of paraquat poisoning.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Paraquat
/
Rats
/
Superoxide Dismutase
/
Male
/
Lipid Peroxidation
/
Catalase
/
Rats, Wistar
/
Oxidative Stress
/
Dose-Response Relationship, Drug
/
Erythrocytes
Type of study:
Evaluation studies
Language:
English
Journal:
Indian J Exp Biol
Year:
2007
Type:
Article
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