Inhibitory effect of piceatannol, a protein tyrosine kinase inhibitor, on asexual maturation of Plasmodium falciparum.
Indian J Exp Biol
;
1999 Apr; 37(4): 418-20
Article
in English
| IMSEAR
| ID: sea-60530
ABSTRACT
This report describes the effect of piceatannol (3,4,3',5'-tetrahydroxy trans stilbene), a plant secondary natural product, on protein tyrosine kinase (PTK) activity in different stages of P. falciparum grown in vitro. Piceatannol inhibited PTK activity in trophozoites and schizonts suggesting that PTK may be important in the initial asexual maturation of the parasite. Inhibition of PTK activity by piceatannol may thus provide new insights into more specific tools for chemotherapeutic interventions for P. falciparum.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Plasmodium falciparum
/
Stilbenes
/
Protein-Tyrosine Kinases
/
Enzyme Inhibitors
/
Animals
/
Antimalarials
Language:
English
Journal:
Indian J Exp Biol
Year:
1999
Type:
Article
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