Expression of mu-opioid receptors in developing rat spinal cord: an autoradiographic study.
Indian J Exp Biol
;
2004 May; 42(5): 533-7
Article
in English
| IMSEAR
| ID: sea-60546
ABSTRACT
The expression of mu-opioid receptors in the developing rat spinal cord (Postnatal days 7, 14, 30) was studied by autoradiography using [3H]DAMGO. When compared to camera lucida drawings, the receptor was noted over the entire gray matter and dorsal root ganglia at postnatal days 7 and 14. At postnatal day 30, the receptor expression decreased over the gray matter except the superficial laminae (laminae I and II). At all age groups studied, a higher expression of the receptor was noted over the superficial laminae. The study shows that micro-opioid receptors appears early in postnatal development and attains mature receptor distribution relatively late in ontogeny, suggesting a possible role in the normal development of nervous system. This is affirmed by an impairment of psychomotor development in babies born to mothers, addicted to opiates.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Spinal Cord
/
Autoradiography
/
Time Factors
/
Rats, Wistar
/
Receptors, Opioid, mu
/
Animals
/
Models, Anatomic
Type of study:
Prognostic study
Language:
English
Journal:
Indian J Exp Biol
Year:
2004
Type:
Article
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