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Evaluation of the modulatory influence of food additive-garam masala on hepatic detoxication system.
Indian J Exp Biol ; 1992 Dec; 30(12): 1142-5
Article in English | IMSEAR | ID: sea-60694
ABSTRACT
Potential chemopreventive role of an Indian food additive-garam masala has been assessed through its impact on the hepatic levels of detoxication enzymes like glutathione S-transferase (GST), cytochrome b5 (cyt. b5) and cytochrome P-450 (cyt. P-450), and acid soluble sulfhydryl (-SH) content in 8-9 weeks old Swiss albino mice of either sex fed on the 0.5%, 1.0% and 1.5% (w/w) garam masala in the diet for 10 days. The data from this short term study revealed the significant but dose-independent alteration in the levels of detoxication system enzymes. The results suggest the possible chemopreventive potency of this widely used food additive by being a bifunctional inducer of detoxication system.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Female / Male / Inactivation, Metabolic / Cytochromes b5 / Spices / Cytochrome P-450 Enzyme System / Food Additives / Glutathione Transferase / Liver / Animals Language: English Journal: Indian J Exp Biol Year: 1992 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Female / Male / Inactivation, Metabolic / Cytochromes b5 / Spices / Cytochrome P-450 Enzyme System / Food Additives / Glutathione Transferase / Liver / Animals Language: English Journal: Indian J Exp Biol Year: 1992 Type: Article