Natural killer cells in HIV-1 infection: role of NK cell-mediated non-cytolytic mechanisms in pathogenesis of HIV-1 infection.
Indian J Exp Biol
;
2003 Nov; 41(11): 1219-25
Article
in English
| IMSEAR
| ID: sea-60719
ABSTRACT
Natural killer (NK) cells exhibit both cytolytic and non-cytolytic effector functions against HIV-infected targets. Their precise role in immunopathogenesis of HIV-1 infection is yet to be fully understood. This review addresses the non-cytolytic functions exhibited by NK cells, their potential role in pathogenesis of HIV-1 infection and the effect of HIV-1 viremia on NK cell functions. Activated NK cells are capable of secreting CC-chemokines and suppressing HIV-1 replication in a non-cytolytic fashion. However, HIV-1 viremia suppresses the ability of NK cells to secrete CC-chemokines. Suppression of HIV-1 viremia by highly active antiretroviral therapy (HAART) restores the ability of NK cells to secrete CC-chemokines and suppress endogenous HIV-1 replication by non-cytolytic mechanisms. Better understanding of the mechanisms involved in HIV-1-NK cell interactions would be helpful in delineating novel therapeutic strategics against HIV-1.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Virus Replication
/
Humans
/
Killer Cells, Natural
/
HIV Infections
/
HIV-1
/
CD8-Positive T-Lymphocytes
/
Anti-HIV Agents
/
Chemokines, CC
/
Antiretroviral Therapy, Highly Active
Type of study:
Etiology study
Language:
English
Journal:
Indian J Exp Biol
Year:
2003
Type:
Article
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