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Mechanism of anti-stress activity of Ocimum sanctum Linn, eugenol and Tinospora malabarica in experimental animals.
Indian J Exp Biol ; 1992 Jul; 30(7): 592-6
Article in English | IMSEAR | ID: sea-60722
ABSTRACT
Effects of restraint stress (RS) and its modulation by O. sanctum (Os), eugenol and T. malabarica (Tm) were evaluated on some biochemical and biophysical parameters in rats. RS induced elevations in blood glucose and urea levels, were unaffected by either Os, eugenol or Tm pretreatment. However, both Os and eugenol lowered RS-induced cholesterol levels. RS also caused a generalized increase in enzyme activity and Os, eugenol or Tm effectively lowered the RS-induced elevations in lactate dehydrogenase (LDH) and alkaline phosphatase. RS also induced (a) increased membrane protein clusterization, (b) increased membrane fluidity and (c) reduced membrane thickness--in RBC membrane, whereas, the effects on the synaptosomal membrane were less marked. The RS-induced changes in RBC membrane dynamics were attenuated/reversed by Os, eugenol or Tm, in a differential manner. These biochemical and membrane changes during Rs and their modulation by the adaptogens are discussed in light of the possible mechanisms of action of these agents, during such aversive stimuli.
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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Rats / Stress, Physiological / Synaptosomes / Blood / Male / Eugenol / Plant Extracts / Cell Membrane / Rats, Wistar / Magnoliopsida Language: English Journal: Indian J Exp Biol Year: 1992 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Rats / Stress, Physiological / Synaptosomes / Blood / Male / Eugenol / Plant Extracts / Cell Membrane / Rats, Wistar / Magnoliopsida Language: English Journal: Indian J Exp Biol Year: 1992 Type: Article