Flow cytometric analysis of T4:T8 splenic cell during dengue virus infection of mice.
Indian J Exp Biol
;
1995 Nov; 33(11): 816-23
Article
in English
| IMSEAR
| ID: sea-60743
ABSTRACT
The present study was undertaken to investigate the effect of dengue type 2 virus (DV) and DV-induced cytokines (CF and CF2) on T lymphocyte subpopulations of spleen by flow cytometry. Following DV-ic inoculation in mice the percent number of CD4+ and CD8+ lymphocytes in the spleen was reduced, the peak reduction in both was observed on the 6th day post-inoculation (p.i.). Intravenous inoculation of CF or CF2 in mice also decreased the percent number of CD4+ as well as CD8+ T lymphocytes subpopulation in the spleen, the maximum reduction being observed at 1 and 2 hr, respectively. The reduction in T lymphocyte subpopulation by CF and CF2 was found to be dose dependent. Thus, the alterations of T lymphocyte subpopulations during DV infection are mediated via cytokines.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Spleen
/
Cytokines
/
CD4-CD8 Ratio
/
Dengue
/
Flow Cytometry
/
Animals
/
Mice
/
Mice, Inbred Strains
Language:
English
Journal:
Indian J Exp Biol
Year:
1995
Type:
Article
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