Anticonvulsant profile of Siotone granules, a herbal preparation.
Indian J Exp Biol
;
1998 Jul; 36(7): 658-62
Article
in English
| IMSEAR
| ID: sea-60746
ABSTRACT
Siotone granule, a herbal psychotropic formulation was tested for its effectiveness in various models of convulsions in animals. S. granule (100 and 200 mg/kg) offered significant protection against pentylenetetrazol-, maximal electroshock- and strychnine-induced convulsions. In hypoxic stress-induced convulsions only 200 mg/kg was effective. It also reduced percent mortality per se and rendered total protection when given in combination with sub-protective dose of diazepam (0.5 mg/kg) and MK-801 (0.1 mg/kg) against pentylenetetrazol-induced convulsions. The anticonvulsant action of S. granule was blocked by flumazenil (4 mg/kg) suggesting the involvement of GABAergic mechanism.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Female
/
Male
/
Rats, Wistar
/
Drug Evaluation, Preclinical
/
Animals
/
Medicine, Ayurvedic
/
Mice
/
Anticonvulsants
Language:
English
Journal:
Indian J Exp Biol
Year:
1998
Type:
Article
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