Antitumor effect of cisplatin against murine ascites Dalton's lymphoma.
Indian J Exp Biol
;
1994 Mar; 32(3): 155-62
Article
in English
| IMSEAR
| ID: sea-60765
ABSTRACT
Cisplatin treatment brings about complete regression of ascites Dalton's lymphoma in mice. In the present study various steps involved during the tumor regression are examined using some biochemical and morphological parameters. During tumor regression, ascites fluid volume decreases sharply and there is an increase in carbohydrates and decrease in protein contents in the ascites supernatant after cisplatin treatment in vivo. Cisplatin treatment brings about definite changes in the arrangement/movement of surface membrane ruffles/blebs of tumor cells and causes infiltration of leukocytes (neutrophils, monocytes, lymphocytes) towards tumor cells. Membrane vesicles and vacuoles are also formed before the disintegration and lysis of tumor cells.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Ascites
/
Neoplastic Stem Cells
/
Lymphoma, Non-Hodgkin
/
Remission Induction
/
Carbohydrates
/
Microscopy, Electron, Scanning
/
Cisplatin
/
Animals
/
Mice
/
Neoplasm Proteins
Language:
English
Journal:
Indian J Exp Biol
Year:
1994
Type:
Article
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