Involvement of dopamine D2 and 5-HT1A receptors in roxindole-induced antinociception.
Indian J Exp Biol
;
1999 Mar; 37(3): 234-7
Article
in English
| IMSEAR
| ID: sea-60788
ABSTRACT
Roxindole, a DA D2 receptor agonist (2-16 mg/kg) produced dose-dependent increase in percentage antinociception. The effect which was blocked by DA D2 antagonist (-)sulpiride (50 mg/kg) and 5-HT1A receptor antagonist (-) pindolol (5 mg/kg). Roxindole (4 and 8 mg/kg) reversed both naloxone (20 mg/kg)-induced hyperalgesia and reserpine (2 mg/kg)-induced hyperalgesia. This reversal was sensitive to blockade by both (-)sulpiride (50 mg/kg) and (-) pindolol (5 mg/kg). The present study suggests that roxindole-induced antinociception is mediated by postsynaptic DA D2 and 5-HT1A receptors.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pindolol
/
Pyridines
/
Reserpine
/
Sulpiride
/
Nociceptors
/
Receptors, Serotonin
/
Receptors, Dopamine D2
/
Dopamine Agonists
/
Receptors, Serotonin, 5-HT1
/
Analgesics
Language:
English
Journal:
Indian J Exp Biol
Year:
1999
Type:
Article
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