Effect of diethylcarbamazine on acetylcholine and gamma amino butyric acid in Setaria digitata.
Indian J Exp Biol
;
1992 Oct; 30(10): 920-2
Article
in English
| IMSEAR
| ID: sea-60920
ABSTRACT
In vitro studies on the effect of neurotransmitter amino acids and amines on the motility of S. digitata showed that acetylcholine (Ach) had a stimulatory and gama amino butyric acid (GABA) an inhibitory effect on the parasite. When the worms were incubated in different concentrations of diethylcarbamazine there was a significant dose related increase in the level of Ach, and the level of GABA remained unchanged. Inhibition of acetylcholine esterase activity by diethylcarbamazine caused the accumulation of Ach in the synapses resulting in receptor desensitization and after a momentary stimulation causes paralysis of the parasite.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Acetylcholinesterase
/
Acetylcholine
/
Setaria Nematode
/
Diethylcarbamazine
/
Gamma-Aminobutyric Acid
/
Glutamate Decarboxylase
/
Animals
/
Movement
Language:
English
Journal:
Indian J Exp Biol
Year:
1992
Type:
Article
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