Serotonin and benzylamine oxidation by type A and type B MAO of rat brain in presence of organophosphate pesticides.
Indian J Exp Biol
;
2001 Aug; 39(8): 802-6
Article
in English
| IMSEAR
| ID: sea-61036
ABSTRACT
Organophosphate (OP) pesticides, monocrotophos (MCP), dichlorvos (DDVP) and phosphamidon significantly inhibit both MAO-A and MAO-B activities in rat brain mitochondria. The inhibition of MAO-A by MCP is reversible whereas the inhibition by DDVP and phosphamidon is irreversible. MAO-B is inhibited irreversibly by all these organophosphates suggesting that the mechanism of action of OP pesticides is through phosphorylation of serine residue present in active centre of MAO.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Organophosphorus Compounds
/
Oxidation-Reduction
/
Rats
/
Benzylamines
/
Brain
/
Male
/
Serotonin
/
Rats, Wistar
/
Insecticides
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
2001
Type:
Article
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