Arsenic induced free radical toxicity in brain of mice.
Indian J Exp Biol
;
2004 May; 42(5): 495-8
Article
in English
| IMSEAR
| ID: sea-61096
ABSTRACT
The present study was designed to investigate the in vivo effects of oral administration of arsenic trioxide (As2O3; 0.5 and 1 mg/kg body weight/day for 45 days) on cerebral hemispheres and cerebellum in male mice, Mus musculus. Arsenic reduced the concentration of glutathione (GSH) in cerebral hemisphere and cerebellum at both the dose levels; while increased lipid peroxidation (LPO) in cerebral hemisphere and cerebellum regions. Further, the activities of antioxidant enzymes viz., superoxide dismutase and catalase also declined in these two regions with dose indicating oxidative stress. This effect is caused by the action of reactive oxygen species (ROS) induced by arsenic exposure.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Oxygen
/
Arsenic
/
Superoxide Dismutase
/
Telencephalon
/
Brain
/
Male
/
Lipid Peroxidation
/
Cerebellum
/
Reactive Oxygen Species
/
Oxidative Stress
Language:
English
Journal:
Indian J Exp Biol
Year:
2004
Type:
Article
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