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Phytochemical investigation and evaluation of anti-inflammatory and anti-arthritic activities of essential oil of Strobilanthus ixiocephala Benth.
Indian J Exp Biol ; 2003 Aug; 41(8): 890-4
Article in English | IMSEAR | ID: sea-61211
ABSTRACT
Column chromatographic fractionation of essential oil obtained by hydrodistillation from the flowering tops of S. ixiocephala resulted in the isolation of beta-caryophyllene, fenchyl acetate, T-cadinol and a new sesquiterpene alcohol for which a name ixiocephol has been proposed. The beta-caryophyllene and fenchyl acetate were identified by Co-TLC with authentic samples whereas T-cadinol and ixiocephol were structurally elucidated by UV, IR, 1H NMR, 13C NMR and Mass spectral data. The GC-MS analysis of the essential oil has also revealed the presence of various monoterpenoids and sesquiterpenoids. The essential oil of S. ixiocephala demonstrated a dose dependant anti-inflammatory activity in carrageenan-induced rat paw oedema. It has also revealed good activity in cotton pellet granuloma and adjuvant induced arthritis model in rats.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Arthritis, Experimental / Rats / Female / Male / Oils, Volatile / Granuloma, Foreign-Body / Anti-Inflammatory Agents, Non-Steroidal / Rats, Wistar / Acanthaceae / Disease Models, Animal Language: English Journal: Indian J Exp Biol Year: 2003 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Arthritis, Experimental / Rats / Female / Male / Oils, Volatile / Granuloma, Foreign-Body / Anti-Inflammatory Agents, Non-Steroidal / Rats, Wistar / Acanthaceae / Disease Models, Animal Language: English Journal: Indian J Exp Biol Year: 2003 Type: Article