Signal transduction events in mammalian cells in response to ionizing radiation.
Indian J Exp Biol
;
2001 Aug; 39(8): 727-34
Article
in English
| IMSEAR
| ID: sea-61243
ABSTRACT
Ionizing radiations elicit a variety of biological effects in mammalian cells. In recent years altered signal transduction has been recognized as a key cellular response to ionizing radiation. Several oncogenes, the products of which are components of signal transduction pathways and which are over-expressed in many tumors, are specifically induced in cells exposed to radiation. It has also become evident that the oncogene ras and the serine/threonine protein kinase oncogenes raf and PKC confer radio-resistance to tumor cells. Modulation of these genes or their activity by natural compounds may offer a strategy to treat cancer by enhancing radiation-induced apoptosis of tumor cells.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Oncogenes
/
Radiation, Ionizing
/
Radiation Tolerance
/
Proto-Oncogenes
/
Humans
/
Signal Transduction
/
Apoptosis
/
Animals
/
Mammals
Language:
English
Journal:
Indian J Exp Biol
Year:
2001
Type:
Article
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