Effect of cadmium and zinc-metallothionein on methemoglobin and nitric oxide in dimethylnitrosamine treated rats.
Indian J Exp Biol
;
2001 May; 39(5): 487-9
Article
in English
| IMSEAR
| ID: sea-61258
ABSTRACT
Protective effects of metallothionein (MT) have been studied against dimethylnitosamine (DMN) toxicity in laboratory rats. MT was induced by feeding rats on repeated sublethal doses of cadmium and zinc. These rats were subsequently administered DMN. Methemoglobin and nitric oxides, the established markers of DMN toxicity, were estimated in the blood samples of MT protected rats. Preinduction of MT decreased methemoglobin and ameliorated the generation of nitric oxides. Antioxidative effects of MT may have manifested these results, however, an effect on N-nitrosation is also speculated.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Zinc
/
Male
/
Cadmium
/
Methemoglobin
/
Carcinogens
/
Rats, Wistar
/
Dimethylnitrosamine
/
Animals
/
Metallothionein
Language:
English
Journal:
Indian J Exp Biol
Year:
2001
Type:
Article
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