Effect of centrally administered nitric oxide modulators in Brewer's yeast-induced nociception in rats.
Indian J Exp Biol
;
2000 Nov; 38(11): 1123-8
Article
in English
| IMSEAR
| ID: sea-61265
ABSTRACT
Possible modulation of Brewer's yeast-induced nociception by centrally (icv) administered nitric oxide (NO) modulators, viz., NO synthase (NOS) inhibitors, NO precursor, donors, scavengers and co-administration of NO donor (SIN-1) with NOS inhibitor (L-NAME) and NO scavenger (Hb) was investigated in rats. Administration of NOS inhibitors and NO scavenger Hb increased the pain threshold capacity significantly, whereas NO donors SIN-1, SNP and NO precursor L-arginine were found to be hyperalgesic. D-arginine, the inactive isomer of L-arginine and methylene blue, inhibitor of soluble guanylate cyclase failed to alter the nociceptive behaviour in rats. Co-administration of SIN-1 with L-NAME and Hb found to increase the nociceptive threshold. The results indicate, that centrally administered NO modulators alter the nociceptive transmission induced by Brewer's yeast in rats.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pain
/
Rats
/
Saccharomyces cerevisiae
/
Male
/
Rats, Wistar
/
Pain Threshold
/
Nitric Oxide Synthase
/
Nitric Oxide Donors
/
Enzyme Inhibitors
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
2000
Type:
Article
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