Regulation of red cell acetylcholinesterase activity in diabetes mellitus.
Indian J Exp Biol
;
1990 Mar; 28(3): 234-6
Article
in English
| IMSEAR
| ID: sea-61287
ABSTRACT
Despite the fact that the significance of red cell membrane acetylcholinesterase (AChE) is unknown, this enzyme of red cell assumes importance since many of its properties have been found to be similar to purified enzyme form of brain tissues. Our investigations on the effect of insulin-dependent diabetes mellitus on red cell AChE revealed that the activity of this enzyme is significantly decreased in diabetes. Insulin treatment restored the activity to the normal level. Solubilization of normal, diabetic and insulin treated diabetic red cell membranes with Triton X-100 (0.2% v/v) caused a general decline in AChE activity, however the per cent decline in activity of diabetic enzyme was lower as compared to normal and insulin treated conditions. From our results it is inferred that the decreased red cell AChE activity in diabetes is due to lesser number of active enzyme molecules and also due to altered membrane microenvironment.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Polyethylene Glycols
/
Acetylcholinesterase
/
Humans
/
Male
/
Octoxynol
/
Adult
/
Detergents
/
Diabetes Mellitus, Type 1
/
Erythrocyte Membrane
/
Insulin
Language:
English
Journal:
Indian J Exp Biol
Year:
1990
Type:
Article
Similar
MEDLINE
...
LILACS
LIS