Effects of centchroman, a synthetic estrogen antagonist on the fertility of female hamsters.
Indian J Exp Biol
;
1990 Aug; 28(8): 717-20
Article
in English
| IMSEAR
| ID: sea-61304
ABSTRACT
Centchroman (3, 4-trans-2, 2-dimethyl-3-phenyl-4-p-beta-pyrrolidinoethoxy-phenyl-7-methoxy-chroman) , a non-steroidal, estrogen antagonist, injected subcutaneously (2 mg/kg body wt) on days 1, 2 and 3 post-coitum in hamsters, prevented implantation in 70% of the animals. A significant decrease in the circulating levels of estradiol and progesterone was observed on day 4 post-coitum as compared to control animals following the treatment of centchroman. The activities of various lysosomal enzymes were also found diminished in the treated animals. This study shows that centchroman may act as an anti-implantation agent in hamsters indicating that estrogen plays a key role during the process of ovum implantation in this species.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Embryo Implantation
/
Gonadal Steroid Hormones
/
Uterus
/
Female
/
Male
/
Pregnancy
/
Centchroman
/
Cricetinae
/
Mesocricetus
/
Estrogens
Language:
English
Journal:
Indian J Exp Biol
Year:
1990
Type:
Article
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