Hypoglycemic effects of Coccinia indica: inhibition of key gluconeogenic enzyme, glucose-6-phosphatase.
Indian J Exp Biol
;
1992 May; 30(5): 418-20
Article
in English
| IMSEAR
| ID: sea-61430
ABSTRACT
Coccinia indica (Family Cucurbitaceae, locally known as telakucha) leaves were extracted with 95% ethanol. Following evaporation of the solvents, the residue was suspended in distilled water. When this suspension was fed orally to male normal-fed and 48-hr starved rats, the blood glucose was lowered 21% (P less than 0.01) in normal-fed and 24% (P less than 0.001) in 48-hr starved animals respectively. Starvation had induced a 3-fold increase in the activity of glucose-6-phosphatase and this activity was depressed 19% (P less than 0.05) by extract feeding while basal activity of the enzyme in normal-fed rats remained unaffected. Consistent with the depression of glucose-6-phosphatase, urea cycle enzyme arginase was also depressed 21% (P less than 0.001) and 12% (P less than 0.01) in the liver of 48 hr-starved and normal-fed animals respectively. Unlike glucose-6-phosphatase, starvation induced levels of gluconeogenic enzymes alanine aminotransferase and aspartate aminotransferase were not affected by Coccinia extract. These results suggest that the hypoglycemic effect of C. indica is partly due to the repression of the key gluconeogenic enzyme glucose-6-phosphatase.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Arginase
/
Plants, Medicinal
/
Rats
/
Bangladesh
/
Blood Glucose
/
Male
/
Plant Extracts
/
Glucose-6-Phosphatase
/
Gluconeogenesis
/
Hypoglycemic Agents
Country/Region as subject:
Asia
Language:
English
Journal:
Indian J Exp Biol
Year:
1992
Type:
Article
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