Effect of aqueous leaf extract of Irvingia gabonensis on gastrointestinal tract in rodents.
Indian J Exp Biol
;
2004 Aug; 42(8): 787-91
Article
in English
| IMSEAR
| ID: sea-61484
ABSTRACT
Effect of the aqueous leaf extract of I. gabonensis on the gastrointestinal tract was investigated on isolated rabbit jejunum, guinea pig ileum, gastrointestinal motility, castor oil-induced diarrhoea in mice and castor oil-induced fluid accumulation in rats. The results showed that the extract exhibited a concentration-dependent relaxation of spontaneous pendular movement of isolated rabbit jejunum and guinea pig ileum, and attenuated both acetylcholine-induced contraction of rabbit jejunum and histamine-induced contraction of guinea pig ileum. The extract (100, 200 and 400 mg/kg) also caused a significant dose-dependent decrease of gastrointestinal motility in mice (40.12, 39.45 and 37.45%), intestinal fluid accumulation in rats (71.43, 81.63 and 83.27%), and remarkably protected mice against castor oil-induced diarrhoea [58.33, 75 and 91.67% (Di Carlo score)] respectively. Preliminary phytochemical screening of the aqueous leaf extract of I. gabonensis revealed the presence of saponins, tannins, phenols and phlobatanins.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rabbits
/
Rats
/
Female
/
Male
/
Plant Extracts
/
Cellulose
/
Rats, Wistar
/
Simaroubaceae
/
Gastrointestinal Tract
/
Diarrhea
Language:
English
Journal:
Indian J Exp Biol
Year:
2004
Type:
Article
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