Receptor-operated calcium-channels in isolated rabbit jejunum.
Indian J Exp Biol
;
1992 Feb; 30(2): 107-9
Article
in English
| IMSEAR
| ID: sea-61500
ABSTRACT
Calcium channels were studied in isolated spontaneously rhythmic rabbit jejunum using the muscarinic agonist carbachol as stimulant. Carbachol failed to produce the characteristic phasic and tonic components of smooth muscle contractions. A variety of chemically distinct calcium antagonists, viz. bepridil, diltiazem, isradipine (PN 200-110), nifedipine, and verapamil, non-competitively inhibited the contractions. Diltiazem was most potent (-logIC50 = 8.30) and bepridil least potent (-logIC50 = 6.19) in inhibiting the contractions. The findings conclude with the presence of pharmacologically distinct receptor-operated calcium-channels, besides the potential-dependent calcium-channels, in the rabbit jejunum.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rabbits
/
Carbachol
/
Calcium Channel Blockers
/
Calcium Channels
/
Dose-Response Relationship, Drug
/
Jejunum
/
Animals
/
Muscle Contraction
/
Muscle, Smooth
Language:
English
Journal:
Indian J Exp Biol
Year:
1992
Type:
Article
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