Effect of poly herbal formulation, EuMil, on neurochemical perturbations induced by chronic stress.
Indian J Exp Biol
;
2002 Oct; 40(10): 1161-3
Article
in English
| IMSEAR
| ID: sea-61704
ABSTRACT
EuMil, a polyherbal formulation consisting of standardised extracts of Withania somnifera (L) Dunal, Ocimum sanctum L, Asparagus racemosus Wilid and Emblica officinalis Gaertn., is used as an anti-stress agent to attenuate the various aspects of stress related disorders. In the present study, the neurochemical mechanisms underlying the anti-stress activity of EuMil were evaluated by measuring the rat brain monoamine neurotransmitter levels and tribulin activity. Chronic electroshock stress (14 days) significantly decreased the nor-adrenaline (NA) and dopamine (DA) levels in frontal Cortex, pons-medulla, hypothalamus, hippocampus and striatal, hypothalamal region, respectively, and increased the 5-hydroxytryptamine (5HT) level in frontal cortex, pons medulla, hypothalamus and hippocampus. Chronic stress, also increased the rat brain tribulin activity. EuMil (100 mg/kg, p.o., 14 days) treatment normalized the perturbed regional NA, DA, 5HT concentrations, induced by chronic stress. EuMil also significantly attenuated the stress-induced increase in the rat brain tribulin activity. The amelioration of chronic stress-induced neurochemical perturbations by EuMil explains the neurochemical mechanisms underlying the observed putative anti-stress activity of the product.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Stress, Physiological
/
Male
/
Chronic Disease
/
Rats, Wistar
/
Neurotransmitter Agents
/
Herbal Medicine
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
2002
Type:
Article
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