Additive effect of alcohol and nicotine on lipid metabolism in rats.
Indian J Exp Biol
;
1993 Mar; 31(3): 270-4
Article
in English
| IMSEAR
| ID: sea-61714
ABSTRACT
Administration of alcohol along with nicotine in rats showed an increase in the concentration of cholesterol, triglycerides, phospholipids and free fatty acids in serum and various tissues compared to that of alcohol fed rats. The increased cholesterogenesis was evidenced by the increased activity of HMG CoA reductase, increased incorporation of labelled acetate in to cholesterol and decreased hepatic degradation of cholesterol to bile acids. The concentration of cholesterol in HDL lipoprotein fraction decreased, while in LDL + VLDL fraction increased. Administration of nicotine along with alcohol is found to enhance the lipogenic tendency of alcohol in rats.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Male
/
Rats, Sprague-Dawley
/
Ethanol
/
Drug Synergism
/
Lipid Metabolism
/
Animals
/
Nicotine
Language:
English
Journal:
Indian J Exp Biol
Year:
1993
Type:
Article
Similar
MEDLINE
...
LILACS
LIS