Your browser doesn't support javascript.
loading
H2O2-induced lipid peroxidation in mitochondria of pulmonary vascular smooth muscle tissue and its modification by DFO, DMTU and DIDS.
Indian J Exp Biol ; 1996 Dec; 34(12): 1220-3
Article in English | IMSEAR | ID: sea-61740
ABSTRACT
Treatment of bovine pulmonary artery smooth muscle tissue mitochondria with H2O2 stimulated iron release, hydroxyl radical (OH) production and lipid peroxidation. Pretreatment of mitochondria with deferoxamine (DFO) and dimethyl thiourea (DMTU) prevented OH production and markedly reduced lipid peroxidation without appreciably altering iron release caused by H2O2. Simultaneous treatment of either DFO or DMTU with H2O2 significantly reduced lipid peroxidation and also prevented OH production without causing marked decrease in iron release. In contrast, addition of DFO or DMTU even 2 min after treatment of the mitochondria with H2O2 did not significantly altered iron release, OH production and lipid peroxidation. Pretreatment of the mitochondria with 4,4'-dithiocyano-2,2'-disulfonic acid stilbene (DIDS) markedly reduced lipid peroxidation without appreciably altering the increase in OH production and iron release caused by H2O2.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Thiourea / Cattle / Lipid Peroxidation / Pulmonary Circulation / Free Radical Scavengers / 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid / Deferoxamine / Hydrogen Peroxide / Animals / Mitochondria, Muscle Language: English Journal: Indian J Exp Biol Year: 1996 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: IMSEAR (South-East Asia) Main subject: Thiourea / Cattle / Lipid Peroxidation / Pulmonary Circulation / Free Radical Scavengers / 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid / Deferoxamine / Hydrogen Peroxide / Animals / Mitochondria, Muscle Language: English Journal: Indian J Exp Biol Year: 1996 Type: Article