Altered lipid peroxidation and antioxidant potential in human uterine tumors.
Indian J Exp Biol
;
1999 May; 37(5): 439-43
Article
in English
| IMSEAR
| ID: sea-61883
ABSTRACT
A comparative study of lipid peroxidation and antioxidant potential has been made in human uterus and uterine tumor. Two types of uterine tumor used are tumor (I), a fibroid which is the commonest benign solid tumor in uterus and tumor (II), an adenomyoma. Tumor microsomes are less susceptible to lipid peroxidation induced by both enzymic (NADPH-ADP-Fe3+ and xanthine-xanthine-oxidase) and non-enzymic (ascorbate-Fe2+) systems except in the case of tumor (II) microsomes when induced with xanthine-xanthine oxidase. Resistance of tumor microsomes to lipid peroxidation is associated with the low content of substrates in the form of polyunsaturated fatty acids (PUFAs), higher level of alpha-tocopherol, reduced glutathione and protein thiols and altered enzymic antioxidant potential (catalase and superoxide dismutase).
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Uterine Neoplasms
/
Vitamin E
/
Female
/
Humans
/
Lipid Peroxidation
/
Fatty Acids
/
Glutathione
/
Antioxidants
Language:
English
Journal:
Indian J Exp Biol
Year:
1999
Type:
Article
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