Pharmacological and immunological evaluation of scorpion (Heterometrus bengalensis) venom antiserum.
Indian J Exp Biol
;
1989 Jan; 27(1): 47-51
Article
in English
| IMSEAR
| ID: sea-61948
ABSTRACT
An antiserum was prepared for the first time against the venom of a common scorpion, H. bengalensis, by hyperimmunization of rabbit. This antiserum showed positive precipitin bands in immunogeldiffusion and immunoelectrophoresis. The serum showed a high titre value tested by indirect haemagglutination test. The antiserum developed in rabbit protected mice against the lethal action of the venom. Smooth muscle contractile response of venom on guinea pig ileum, and rat uterus was antagonized by the antiserum. This antiserum effectively antagonized the venom induced neuromuscular paralysis tested on rat phrenic nerve diaphragm and chick biventer cervices. Antiserum also protected the venom-induced cardiac arrest tested on isolated guineapig heart and auricle preparations.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Scorpion Venoms
/
Hemagglutination Tests
/
Immunoelectrophoresis
/
Antivenins
/
Immunodiffusion
/
Guinea Pigs
/
Animals
/
Mice
Language:
English
Journal:
Indian J Exp Biol
Year:
1989
Type:
Article
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