Protective effect of testosterone against alcohol and paracetamol induced hepatotoxicity in rats.
Indian J Exp Biol
;
1995 Mar; 33(3): 194-200
Article
in English
| IMSEAR
| ID: sea-62000
ABSTRACT
Chronic ethanol and paracetamol consumption, both individually and in combination, caused hepatic changes in rats. Treatment of testosterone (2.5 mg/kg body wt.) to the alcoholic and paracetamol administered rats showed decreased activities of serum transaminases, serum acid and alkaline phosphatases, and decreased levels of hepatic triglycerides, cholesterol and free fatty acids. Concentration of the lipid peroxidation product-malondialdehyde was significantly decreased in the liver after testosterone treatment in alcohol and paracetamol administered groups. Histopathological observations further confirm that testosterone could offer protection against alcohol and paracetamol induced damage to liver in animals.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Testosterone
/
Body Weight
/
Male
/
Rats, Sprague-Dawley
/
Ethanol
/
Eating
/
Lipid Metabolism
/
Liver
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
1995
Type:
Article
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